Understanding How Antiepileptic Drug Side Effects Influence Quality of Life in Epilepsy

Antiepileptic drugs (AEDs) are the cornerstone of epilepsy management, yet their adverse effects (AEs) often compromise patient well‐being. These AEs range from mild somatic symptoms to severe psychiatric and cognitive disturbances, significantly impacting quality of life (QoL) regardless of seizure control. This review compiles current evidence on the spectrum of AED‐related AEs, their influence on QoL, and the differential profiles of older versus newer AEDs. It also examines psychosocial outcomes and strategies to mitigate these impacts—insights essential for personalised treatment planning.