A Review of the Therapeutic Potential of Fungi: Activities Against Severe Diseases and Recent Advances in Fungal Research

Kaur, Amandeep and Sharma, Brij Bhushan and Pandir, Jyoti and Kumari, Poonam and Kaur, Rajneesh and Sharma, Versha (2025) A Review of the Therapeutic Potential of Fungi: Activities Against Severe Diseases and Recent Advances in Fungal Research. International Journal of Innovative Science and Research Technology, 10 (5): 25may1561. pp. 4298-4307. ISSN 2456-2165

Abstract

Some of the most significant medications ever found are derived from fungi, and they have shown to be essential in the treatment of chronic illnesses. Not only have they prevented millions of deaths, but in certain instances, they have altered about the limits of medical advancement. With new businesses entering the market and hoping so use cutting-edge genomic technologies to speed up the discovery process, this might be about to change. This review looks at the path of discovery for both authorized fungal-derived medications and those undergoing clinical trials for long-term illnesses. We address the potential ecological roles of essential chemicals in nature and with how this connects to these application in human medicine. We demonstrate that how compounds meant to prohibit rival fungi, frequently interact with human receptors drug, sometimes with unanticipated benefits, due to conservation of drug receptors between fungi and people. In addition, we map the locations of medications, antimicrobial substances, and hallucinogenic mushrooms like fungal tree and focus on their distribution with that of all fungal metabolites. Lastly, we look at the self-resistance phenomena with fungi and how to predict the mechanism of metabolites and facilitate the drug discovery and lead optimization process.

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