Atypical Presentation of Endogenous Cushing Syndrome

Cushing’s syndrome is a rare disorder with varied clinical manifestations, often leading to delayed diagnosis. We report a case of a 35-year-old woman presenting with worsening dyspnea, secondary amenorrhea, and proximal muscle weakness. Initial evaluation revealed congestive heart failure and poorly controlled diabetes. Further endocrinological workup confirmed ACTH-independent Cushing’s syndrome secondary to an adrenal adenoma. Following surgical adrenalectomy, the patient showed significant clinical improvement. This case highlights the importance of a high index of suspicion for endocrine disorders in patients with systemic symptoms like heart failure and myopathy.