Investigation of the Anti-Inflammatory Activity of Barringtonia asiatica (Lecythidaceae) Ethanolic Leaf Extract in Albino Mice

The leaves of Barringtonia asiatica (Lecythidaceae) have long been employed in traditional medicine for their therapeutic benefits, including anti-inflammatory properties. This study evaluated the anti-inflammatory effects of ethanolic leaf extracts of B. asiatica in vivo using carrageenan-induced paw edema in Swiss albino mice. Mice were administered extract concentrations of 25%, 50%, and 75%, while diclofenac sodium served as a positive control. Phytochemical analysis revealed the presence of flavonoids, saponins, and other bioactive constituents. The 75% extract demonstrated significant anti-inflammatory effects, comparable to diclofenac. Acute oral toxicity testing confirmed the extract's safety. These findings support the traditional medicinal use of B. asiatica and its potential as a safe, plant-based anti-inflammatory agent.