Val66Met and Genetic Predisposition to Obesity, Mood, and Sleep Disorders

Brain-derived Neurotrophic Factor (BDNF) has several polymorphisms, one of the most recognized being the Val66Met polymorphism, which is associated with a range of disorders. This review examines current evidence on Val66Met polymorphism, highlighting how Met allele carriers tend to gain weight, exhibit heightened emotional sensitivity, and experience poor sleep quality. The Met allele consistently emerged as a contributor to disrupted neuroplasticity, impaired emotional regulation, and altered metabolic function. Some strategies, such as lifestyle and nutrition-based interventions, showed positive results in increasing BDNF levels, potentially helping to mitigate these effects. The consequences of Val66Met polymorphism might be aggravated by lifestyle factors such as stress, poor diet, and lack of physical activity. Greater insight into the role of Val66Met may help create more tailored and efficient ways of maintaining physical and mental health.