Comparison of the Effectiveness of Injectable Platelet Rich Fibrin and Microosteoperforation on En Masse Retracton of Maxillary Anterior Teeth: Comparitive Study

Background and Objective: One of the primary concerns for orthodontic patients is the duration of treatment. Shortening this time involves carefully managing the treatment process from the very beginning. 1 Studies have shown that bone resorption is the key factor that limits the speed of tooth movement. As a result, techniques that enhance osteoclast activity can help increase the pace of orthodontic tooth movement. Several methods aimed at accelerating orthodontic treatment have been developed, though their outcomes have been inconsistent. Injectable platelet-rich fibrin (i-PRF) and micro-osteoperforations (MOP) are among the least invasive surgical techniques, as MOP does not require raising a full-thickness flap. Both approaches promote the activity of osteoclasts and osteoblasts. Notably, i-PRF significantly increases the levels of RANKL, MMP8, and IL-1β—key factors involved in bone remodeling. This study aimed to compare the effectiveness of i-PRF and MOP in enhancing the rate of space closure during en masse retraction of the maxillary anterior teeth.  Methods: Twenty-four patients undergoing orthodontic treatment at K.V.G. Dental College and Hospital, all requiring extraction of the maxillary first premolars, were selected and divided into two groups of 12: the i-PRF group and the MOP group. In the i-PRF group, injections were administered into the distobuccal and distolingual periodontal ligament spaces of the maxillary canines twice—once immediately before the start of en masse retraction and again at the second week of retraction. Local anesthesia was used prior to the injections to ensure patient comfort.  Results: The rate of space closure was similar in i-PRF group anf MOP group and the difference between the two groups was not statistically significant...  Interpretation and Conclusion: It was concluded that both injectable platelet rich fibrin and MOP minimally invasive procedure had similar rate of tooth movement which could be an effective enhancing orthodontic treatment efficiency by accelerating tooth movement.